The 31^st Annual Meeting and Symposium of The Korean Society of Applied Pharmacology

Exploring Novel Therapeutic Approaches for Intractable Diseases through Organoid Models

October 6 (Fri), 2023

2F Mugunghwa Hall

Time Program Chair 09:00~ Registration 09:20~09:30 Opening Remarks Greeting from President of KSAP Hyun-Jeong Ko (Kangwon National University) SessionⅠ. Basic Understanding of Organoids in Drug Development Se-Ran Yang (Kangwon National University) 09:30~09:55 Organoids: A new Platform in basic and Translational Research Ji Hun Yang, Next and Bio Inc. 09:55~10:20 Liver Organoid Platform for Disease Modeling and Safety Assessment Myung Jin Son, Korea Research Institute of Bioscience and Biotechnology 10:20~10:45 Patient-derived organoids as a platform for drug screening Minsuh Kim, Korea University 10:45~11:00 Coffee Break Session Ⅱ. Organoids as Disease Models for Innovative Drug Development Hyuk-Jin Cha (Seoul National University) 11:00~11:25 Vascularized liver organoids from human induced pluripotent stem cells: disease modeling & drug screening Jong-Hoon Kim, Korea University 11:25~11:50 Stem Cell-based Therapy of Ischemic Diseases Jae Ho Kim, Pusan National University 11:50~12:15 Dissecting cellular heterogeneity and plasticity of gastric stem cells Jong Kyoung Kim, POSTECH 12:15~13:30 Lunch & Poster Session Plenary Lecture Hyun-Jeong Ko (Kangwon National University) 13:30~14:05 CRISPR/Cas-assisted genetics in intestinal organoids Bon-Kyoung Koo, Institute for Basic Science Session Ⅲ. Innovative Drug Development for Neurodegenerative Diseases Soo Young Kim (Yeungnam University) 14:05~14:30 Anti-Amyloidogenic Effect of a Novel RAGE Modulator Dong-Gyu Jo, Sungkyunkwan University 14:30~14:55 Amyloid Against Amyloid: Dimeric Amyloid Fragment Ameliorates Cognitive Impairments by Direct Clearance of Oligomers and Plaques YoungSoo Kim, Yonsei University 14:55~15:20 Cdk4/6 inhibitor modulates AD pathology, neuroinflammation and cognitive function in a mouse model of AD Hyang-Sook Hoe, KBRI 15:20~15:35 Coffee Break Session IV. Novel Anti-Cancer Drug Development Hyungshin Yim (Hanyang University) 15:35~16:00 Tyrosine kinase-targeting strategies to overcome intractable cancer Keon Wook Kang, Seoul National University 16:00~16:25 Novel immunotherapeutic approach using engineered T cell-derived extracellular vesicles Moon-Chang Baek, Kyungpook National University. 16:25~16:50 The impact of ZEB1-modulated hyaluronan network on lung cancer metastasis Young-Ho Ahn, Ewha Womans University 17:00~17:25 Academic Research Award Lecture Chan Young Shin (Konkuk University) 17:30~18:00 General Assembly Tae Jin Kang (Sahmyook University)

October 6 (Fri), 2023

1F Magnolia Hall

Time Program Chair Session Ⅴ. Outstanding Young Investigators Kwang Hun Chun (Gachon University) & Byung-Seok Kim (Incheon National University) 09:30~09:50 Acetylated tau: A missing link between brain injury and Alzheimer’s disease Min-Kyoo Shin, Seoul National University 09:50~10:10 The role of transcriptional repressor Capicua (CIC) in cancer progression Jiwon Kim, Jeju National University 10:10~10:30 Leveraging transcriptomic signatures and network models to uncover cancer resistance and muscle atrophy Sang-Min Park, Chungnam National University 10:30~10:50 Enhancer activation, Release and Re-targeting in transcription Soohwan Oh, Korea University 10:50~11:10 A non-canonical role for NMDA receptors associated with the antidepressant action of ketamine Ji-Woon Kim, Kyung Hee University 11:10~11:25 Coffee Break Session Ⅵ. JSSX-KSAP Joint Symposium Pil-Hoon Park (Yeungnam University) 11:25~11:50 Artificial Intelligence assisted early drug discovery & current drug pipelines Mi-hyun Kim, Gachon University 11:50~12:15 Current and future application of organoid for drug safety evaluation Tadahiro Shinozawa, Takeda Pharmaceutical Company 12:15~12:40 Next generation quantitative proteomics opens up the new fields of central nervous system barrier studies Yasuo Uchida, Hiroshima University 12:40~13:30 Lunch & Poster Session Session VII. Current Research on Drug Dependence: Academics and Government View Seikwan Oh (Ehwa Womans University) 13:30~14:00 Application of machine intelligence for drug development and preclinical study Daesoo Kim, KAIST 14:00~14:25 Interaction between miR-137 and SYNCRIP for the theragnosis of methamphetamine abstinence: from animals to human Heh-In Im, KIST 14:25~14:50 Evaluation of microdialysis and drug discrimination test on seven NPS in rodents Chan Hyeok Kwon, Pharmacological Research Division, National Institute of Food and Drug Safety Evaluation 14:50~15:10 Coffee Break 15:10~15:35 Assessment of psychological and physical dependence of psychoactive drugs Choon-Gon Jang, Sungkyunkwan University Jaesuk Yun (Chungbuk National University) 15:35~16:00 Risk assessment of the central nervous system effects and the abuse potential of new psychoactive substances Su-Jeong Park, Pharmacological Research Division, National Institute of Food and Drug Safety Evaluation 16:00~16:25 Preclinical evaluations of the abuse potential of new drugs Seong Shoon Yoon, Daegu Haany University 16:25~ Closing Remark

Poster Session

October 6 (Fri), 2023

1F Suryun · Dongbaek Hall

Time Program 09:30~10:30 Poster Set-up 13:00~13:30 Poster Presentation 16:00~17:00 Poster Removal